Synthesis on Scale Symposium

Friday, 12 January 2024 10:00 AM - 4:15 PM EST

123 Bevier Road, Piscataway, NJ, 08854, United States

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Friday, 12 January 2024 10:00 AM - 4:15 PM EST

Rutgers University Department of Chemistry & Chemical Biology, 123 Bevier Road, Piscataway, NJ, 08854, United States.

Join us at the SOSS Chemistry Symposium, presented by the Princeton Section of the American Chemical Society. This enlightening event will take place on Friday, January 12th, 2024, from 10:00 AM to 4:15 PM at the Rutgers University Department of Chemistry & Chemical Biology, 123 Bevier Rd., Piscataway, NJ 08854.

 

This year's theme, "Synthesis on Scale: Process Chemistry in the Pharmaceutical Industry," promises to bring together leading minds in chemistry to discuss and share groundbreaking techniques and innovations. The symposium will feature a series of insightful talks from distinguished speakers, including Harshkumar Patel from Bristol-Myers Squibb, Kevin Campos from Merck, Chris Senanayake from TCG GreenChem, and Prof. Kendall Houk from UCLA. They will cover a range of topics from sustainable synthetic routes, innovations in synthetic chemistry, novel synthetic approaches, to computational elucidation of pericyclic reactions in synthesis and biosynthesis.

 

The event schedule includes:

 

10:00 – 10:10 AM: Welcome and Opening Remarks

Series of Talks from 10:10 AM to 3:10 PM

12:10 – 1:10 PM: Lunch Buffet in the CCB Foyer

3:10 – 3:15 PM: Closing Remarks

3:15 – 4:15 PM: Reception

Your registration includes a coffee and donut breakfast, a buffet lunch, and a reception with beer and wine after the talks.

 

Registration Fees:

 

On-Site Admission: $80 per person

General Admission: $60 per person

Student Admission: $20 per person

 

Parking for this event will be at Lot 54. Parking registration links will be sent via email.

 

We eagerly await your participation in what promises to be a highly engaging and informative symposium!

PACS

Spencer Knapp is Professor of Chemistry and Chemical Biology at Rutgers University. His research has spanned medicinal chemistry (IBD, tuberculosis, and malaria), structural bio- inorganic chemistry (metalloproteins and biological electron transfer), natural products total synthesis, new synthetic methods, and enzyme mechanism and inhibition. He has been active in the Princeton section of the ACS for many years, serving as Chair in 2020, and leading the Fall Organic Chemistry Symposium in 2003, 2009, and 2014. Since 2020, he has organized the Synthesis on Scale Symposium, now in its fifth year, working with co-organizers Jennifer Albaneze-Walker (BMS) and Mukund Chorghade (THINQ Pharma) and PACS representatives David Carrick and Louise Lawter. https://rutchem.rutgers.edu/research/faculty-research/167-knapp-spencer https://scholar.google.com/citations?user=nWhf2QoAAAAJ&hl=en

Contact the Organizer

Learn more aboutKendall N. Houk Kendall N. Houk
Kendall N. Houk
Distinguished Research Professor
Department of Chemistry & Biochemistry, UCLA

K. N. Houk received all his degrees at Harvard, working with R. B. Woodward on experimental tests of orbital symmetry selection rules. In 1968, he joined the faculty at Louisiana State University, moved to the University of Pittsburgh in 1980, and to UCLA in 1986. From 1988-1990, he was Director of the Chemistry Division of the National Science Foundation. He was Chairman of the UCLA Department of Chemistry and Biochemistry from 1991-1994. He was the Saul Winstein Chair in Organic Chemistry from 2009-2021 and is now Distinguished Research Professor. Professor Houk has many awards from the ACS, including the Norris Award in Physical Organc Chemistry, the Computers in Chemistry and Pharmaceutical Sciences Award, the Cope Scholar and Arthur C. Cope Awards, and the Roger Adams Award. He is a member of the American Academy of Arts, the International Academy of Quantum Molecular Sciences, the National Academy of Sciences, and the Chinese Academy of Sciences. He was a Senior Editor of Accounts of Chemical Research from 2005-2015. Houk is an authority on theoretical and computational organic chemistry and collaborates prodigiously with groups all over the world. He has published over 1500 publications and a physical organic chemistry textbook with Pierre Vogel. He has an h-index of 142.

https://www.chem.ucla.edu/houk/

About Kendall N. Houk

Distinguished Research Professor
Department of Chemistry & Biochemistry, UCLA
Learn more aboutHarshkumar Patel Harshkumar Patel
Harshkumar Patel
Principal Scientist
Bristol-Myers Squibb

Dr. Harshkumar Patel is a Principal Scientist working in Chemical Process Development (CPD) at the BMS New-Brunswick site in New Jersey. Harsh is originally from Mumbai, India where he pursued a bachelor’s in pharmacy and Master’s in Pharmaceutical chemistry. In 2012, he moved to the United States and attended University of Utah for doctoral studies in the laboratory of Prof. Matthew Sigman. His Ph.D. thesis focused on development of novel chemical transformations, specifically development of redox-relay enantioselective Heck reactions using Palladium catalysts. He is passionate about developing safe, economic, and sustainable processes to supply high quality active pharmaceutical ingredients (APIs) for the medicines being delivered to patients.

About Harshkumar Patel

Principal Scientist
Bristol-Myers Squibb
Learn more aboutKevin Campos Kevin Campos
Kevin Campos
Vice President - Development Sciences and Clinical Supply
Merck Research Laboratories

Kevin Campos received a B.S. degree in Chemistry from Virginia Tech in 1993. In 1999, he obtained his PhD from Professor David A. Evans at Harvard University. Kevin joined the Department of Process Research at Merck in 1999, and over the last 24 years, he has established himself as a leader in both drug discovery and development of important products at Merck. He is currently Vice President and Head of Process Research and Development, responsible shepherding programs across all modalities from Discovery to Commercial Filing. Under his leadership, several commercial manufacturing routes for novel therapies have been launched, including ZEPATIER™, PREVYMIS™, PIFELTRO™, ZERBAXA™, RECARBRIO™, BRIDION™, WELIREG™, LYFNUA™, and LAGEVRIO™ and his team has been recognized by the US EPA with the Green Chemistry Challenge Award 6 years in a row. He serves as the chairman of the R&D Council of New Jersey and was recognized with the ACS Earle B. Barnes Award for Leadership in Chemical Research Management in 2022.

About Kevin Campos

Vice President - Development Sciences and Clinical Supply
Merck Research Laboratories
Learn more aboutChris Senanayake Chris Senanayake
Chris Senanayake
CEO and CSO
TCGGreenChem

Dr. Chris H. Senanayake was born in Sri Lanka and received a BS degree (First Class) in Sri Lanka. After coming to the United States, he completed his MS at Bowling Green State University with Prof. Thomas Kinstle and his Ph.D. with Prof. James H. Rigby at Wayne State University in 1987. He then spent a postdoctoral period with Prof. Carl R. Johnson. In 1989, he joined the Department of Process Development at Dow Chemical Co., moving in 1990 to Merck. He accepted a position at Sepracor, Inc. in 1996 where he was promoted to Executive Director of Chemical Process Research. In 2002, he joined Boehringer Ingelheim Pharmaceuticals. In 2018, he joined AstaTech BioPharmaceutical Corporation as CEO, where he oversees all subsidiaries including AstaGreen Chem, Inc. in Richmond, VA. In 2019, he became the CSO of TCG Lifesciences Pvt. Ltd. and founded TCG GreenChem Inc. He was also appointed as president of AstaTech Biopharmaceutical. He is the co-author of over 500 papers, patents, book chapters, and review articles, and has more than 115 patents. His development work includes Crixivan, Lunesta, Jardiance, (R,R)-Formotorol, and Desvenlafaxine. Dr. Senanayake is an Editorial Advisory Board member of OPRD, Advanced Synthesis and Catalysis, Beilstein Journal of Organic Chemistry, and the Asian Journal of Organic Chemistry. In 2008, he chaired the Stereochemistry Gordon Conference. In 2010, he received the Siegfried Gold Medal Award for development of practical processes for APIs and Process Chemistry. In 2013, he was named to the Board of Editors for Organic Syntheses. In 2017, he was appointed to the Board of Directors of CURE (connecting Connecticut’s science community). In 2022, he was the recipient of two CEO awards in two separate categories: “Best CEO in the Pharmaceutical Industry - North America” and “Growth Strategy CEO of the Year – USA” from Business Worldwide Magazine. He has also been recognized as one among the “Top 20 Dynamic CEOs of 2022” in The CEO Publication Magazine.

About Chris Senanayake

CEO and CSO
TCGGreenChem
Learn more aboutSpencer Knapp Spencer Knapp
Spencer Knapp
Professor, Symposium Organizer
Rutgers CCB, PACS

About Spencer Knapp

Professor, Symposium Organizer
Rutgers CCB, PACS
Learn more aboutJean Baum Jean Baum
Jean Baum
Distinguished Professor, Vice Provost for Life Science
Rutgers University

About Jean Baum

Distinguished Professor, Vice Provost for Life Science
Rutgers University
Learn more aboutLawrence J. Williams Lawrence J. Williams
Lawrence J. Williams
Professor, Chair
Rutgers CCB

About Lawrence J. Williams

Professor, Chair
Rutgers CCB

About Princeton Section of the American Chemical Society

https://www.princeton-acs.org/ Sponsor Logo

About Bristol-Myers Squibb

https://www.bms.com/ Sponsor Logo

About Merck

https://www.merck.com/ Sponsor Logo

About International Flavors & Fragrances Inc.

https://www.iff.com/ Sponsor Logo

About Ace Glass Incorporated

https://www.aceglass.com Sponsor Logo

About TCG GreenChem

https://tcggreenchem.com/ Sponsor Logo

About ChemScene

https://www.chemscene.com/ Sponsor Logo

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Sessions on Jan 12, 2024

10:00 AM

Opening Remarks

10:00 AM - 10:10 AM
    Jean Baum
    Distinguished Professor, Vice Provost for Life ScienceRutgers University
    Lawrence J. Williams
    Professor, ChairRutgers CCB
    10:10 AM

    Development of a Sustainable Synthetic Route to BMS-986278

    10:10 AM - 11:10 AM
      Harshkumar Patel
      Principal ScientistBristol-Myers Squibb
      Dr. Harshkumar Patel is a Principal Scientist working in Chemical Process Development (CPD) at the BMS New-Brunswick site in New Jersey. Harsh is originally from Mumbai, India where he pursued a bachelor’s in pharmacy and Master’s in Pharmaceutical chemistry. In 2012, he moved to the United States and attended University of Utah for doctoral studies in the laboratory of Prof. Matthew Sigman. His Ph.D. thesis focused on development of novel chemical transformations, specifically development of redox-relay enantioselective Heck reactions using Palladium catalysts. He is passionate about developing safe, economic, and sustainable processes to supply high quality active pharmaceutical ingredients (APIs) for the medicines being delivered to patients.
      11:10 AM

      Innovations in Synthetic Chemistry at Merck: Striving for the Ideal Commercial Manufacturing Process

      11:10 AM - 12:10 PM
        Kevin Campos
        Vice President - Development Sciences and Clinical SupplyMerck Research Laboratories
        Kevin Campos received a B.S. degree in Chemistry from Virginia Tech in 1993. In 1999, he obtained his PhD from Professor David A. Evans at Harvard University. Kevin joined the Department of Process Research at Merck in 1999, and over the last 24 years, he has established himself as a leader in both drug discovery and development of important products at Merck. He is currently Vice President and Head of Process Research and Development, responsible shepherding programs across all modalities from Discovery to Commercial Filing. Under his leadership, several commercial manufacturing routes for novel therapies have been launched, including ZEPATIER™, PREVYMIS™, PIFELTRO™, ZERBAXA™, RECARBRIO™, BRIDION™, WELIREG™, LYFNUA™, and LAGEVRIO™ and his team has been recognized by the US EPA with the Green Chemistry Challenge Award 6 years in a row. He serves as the chairman of the R&D Council of New Jersey and was recognized with the ACS Earle B. Barnes Award for Leadership in Chemical Research Management in 2022.
        12:10 PM

        Lunch Buffet

        12:10 PM - 01:10 PMCCB Foyer
        01:10 PM

        Novel Synthetic Approaches toward Complex API Assembly

        01:10 PM - 02:10 PM
          Chris Senanayake
          CEO and CSOTCGGreenChem
          Dr. Chris H. Senanayake was born in Sri Lanka and received a BS degree (First Class) in Sri Lanka. After coming to the United States, he completed his MS at Bowling Green State University with Prof. Thomas Kinstle and his Ph.D. with Prof. James H. Rigby at Wayne State University in 1987. He then spent a postdoctoral period with Prof. Carl R. Johnson. In 1989, he joined the Department of Process Development at Dow Chemical Co., moving in 1990 to Merck. He accepted a position at Sepracor, Inc. in 1996 where he was promoted to Executive Director of Chemical Process Research. In 2002, he joined Boehringer Ingelheim Pharmaceuticals. In 2018, he joined AstaTech BioPharmaceutical Corporation as CEO, where he oversees all subsidiaries including AstaGreen Chem, Inc. in Richmond, VA. In 2019, he became the CSO of TCG Lifesciences Pvt. Ltd. and founded TCG GreenChem Inc. He was also appointed as president of AstaTech Biopharmaceutical. He is the co-author of over 500 papers, patents, book chapters, and review articles, and has more than 115 patents. His development work includes Crixivan, Lunesta, Jardiance, (R,R)-Formotorol, and Desvenlafaxine. Dr. Senanayake is an Editorial Advisory Board member of OPRD, Advanced Synthesis and Catalysis, Beilstein Journal of Organic Chemistry, and the Asian Journal of Organic Chemistry. In 2008, he chaired the Stereochemistry Gordon Conference. In 2010, he received the Siegfried Gold Medal Award for development of practical processes for APIs and Process Chemistry. In 2013, he was named to the Board of Editors for Organic Syntheses. In 2017, he was appointed to the Board of Directors of CURE (connecting Connecticut’s science community). In 2022, he was the recipient of two CEO awards in two separate categories: “Best CEO in the Pharmaceutical Industry - North America” and “Growth Strategy CEO of the Year – USA” from Business Worldwide Magazine. He has also been recognized as one among the “Top 20 Dynamic CEOs of 2022” in The CEO Publication Magazine.
          02:10 PM

          Pericyclic Reactions in Synthesis and Biosynthesis: Computational Elucidation

          02:10 PM - 03:10 PM
            Kendall N. Houk
            Distinguished Research ProfessorDepartment of Chemistry & Biochemistry, UCLA
            K. N. Houk received all his degrees at Harvard, working with R. B. Woodward on experimental tests of orbital symmetry selection rules. In 1968, he joined the faculty at Louisiana State University, moved to the University of Pittsburgh in 1980, and to UCLA in 1986. From 1988-1990, he was Director of the Chemistry Division of the National Science Foundation. He was Chairman of the UCLA Department of Chemistry and Biochemistry from 1991-1994. He was the Saul Winstein Chair in Organic Chemistry from 2009-2021 and is now Distinguished Research Professor. Professor Houk has many awards from the ACS, including the Norris Award in Physical Organc Chemistry, the Computers in Chemistry and Pharmaceutical Sciences Award, the Cope Scholar and Arthur C. Cope Awards, and the Roger Adams Award. He is a member of the American Academy of Arts, the International Academy of Quantum Molecular Sciences, the National Academy of Sciences, and the Chinese Academy of Sciences. He was a Senior Editor of Accounts of Chemical Research from 2005-2015. Houk is an authority on theoretical and computational organic chemistry and collaborates prodigiously with groups all over the world. He has published over 1500 publications and a physical organic chemistry textbook with Pierre Vogel. He has an h-index of 142.
            https://www.chem.ucla.edu/houk/
            03:10 PM

            Closing Remarks

            03:10 PM - 03:15 PM
              Spencer Knapp
              Professor, Symposium OrganizerRutgers CCB, PACS
              03:15 PM

              Reception

              03:15 PM - 04:15 PMCCB Foyer

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